Figure 18.
Radar plot of the ‘lead hit compounds’ obtained after analysing the ADME properties using SwissADME server. (A) buddlenol-A, (B) citrusin-B, (C) 9-hydroxycanthin-6-one, (D) bruceolline-B, (E) prosopine, (F) fisetinidol, and (G) picrasidine-X. The radar plot determines the drug-likeness properties of the compounds. The optimum range of each property is represented by the pink area of the plot. LIPO = lipophilicity (consensus Log PO/W between -0.5 and 7), SIZE = molecular weight (between 150 and 500 g/mol), POLAR = topological polar surface area (TPSA should be between 20-130 Å2, INSOLU = solubility (Log S value does not exceed -6), INSATU = saturation (fraction of carbons in the sp3 hybridization should not less than 0.25), FLEX = flexibility (number of rotatable bonds should be less than 9).