Table 4.
Lipophilicity and Water solubility properties of the ‘lead hit compounds’ determined using Swiss ADME server.
| Compounds | Lipophilicity |
Water solubility |
|||||
|---|---|---|---|---|---|---|---|
| Consensus Log PO/W | Log S (ESOL) | ESOL Class |
Log S (Ali) | Ali Class |
Log S (SILICOS-IT) | SILICOS-IT Class |
|
| Buddlenol-A | 2.62 | -4.28 | Moderately soluble | -5.03 | Moderately soluble | -5.88 | Moderately soluble |
| Citrusin B | 0.02 | -2.5 | Soluble | -3.3 | Soluble | -1.87 | Soluble |
| 9-Hydroxycanthin-6-one | 1.55 | -1.96 | Very soluble | -0.68 | Very soluble | -4.83 | Moderately soluble |
| Bruceolline-B | -1.78 | -2.16 | Soluble | -2.29 | Soluble | -0.89 | Soluble |
| Prosopine | 3.10 | -3.58 | Soluble | -5.32 | Moderately soluble | -3.77 | Soluble |
| Fisetinidol | 1.22 | -2.37 | Soluble | -2.19 | Soluble | -2.72 | Soluble |
| Picrasidine-X | 1.18 | -2.46 | Soluble | -2.33 | Soluble | -3.02 | Soluble |