Table 7.
Toxicity evaluation of the ‘lead hit compounds’ determined using admetSAR server.
| Compound | AMES Toxicity | Carcinogens | Biodegradation | Acute Oral Toxicity (class) | Rat Acute Toxicity (LD50, mol/kg) |
|---|---|---|---|---|---|
| Buddlenol-A | No (0.77) | No (0.91) | Not readily biodegradable (0.97) | III (0.61) | 2.68 |
| Citrusin-B | No (0.79) | No (0.94) | Not readily biodegradable (0.74) | III (0.74) | 2.26 |
| 9-hydroxycanthin-6-one | Yes(0.71) | No (0.93) | Not readily biodegradable (0.96) | III (0.46) | 1.97 |
| Bruceolline-B | No (0.72) | No (0.94) | Not readily biodegradable (0.96) | III (0.53) | 2.24 |
| Prosopine | No (0.87) | No (0.97) | Not readily biodegradable (0.70) | III (0.71) | 1.93 |
| Fisetinidol | No (0.79) | No (0.93) | Not readily biodegradable (0.89) | II (0.33) | 2.48 |
| Picrasidine-X | No (0.65) | No (0.93) | Not readily biodegradable (0.89) | III (0.68) | 2.31 |