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. 2022 May 19;22:561. doi: 10.1186/s12885-022-09596-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DAB2IP regulates the malignant behavior of CRC cells through HSP90AA1. a CCK8 assay demonstrated that DAB2IP regulated the proliferation of CRC cells by HSP90AA1. *P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001. The data were expressed as mean ± SD, n = 3. b c Apoptosis of CRC cells was regulated by DAB2IP/ HSP90AA1 signal pathway, quantification at the bottom. Apoptosis was analyzed by measuring Annexin V-PE positive cells by flow cytometry. *P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001. The data were expressed as mean ± SD, n = 3. d e Transwell assay and Wound scratch assay demonstrated that DAB2IP regulated the migration of CRC cells by regulating HSP90AA1 expression, quantification at the bottom. *P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001. The data were expressed as mean ± SD, n = 3