Table 1:

different type of emerging tobacco products and the impact on different aspect of hemostasis.

Product	Common brand	Common Flavors	Common Thrombosis-Dependent Mechanisms	Toxicant / Chemical
Electronic cigarettes (e-cigarettes, vapes) Open and Close systems	NJOY, JUUL, Vuse, Mart Ten, Blu, Logic	Fruits, mint, menthol[176]	Endothelial dysfunction[177–179] Platelet activation[27] Coagulation[180–182] Oxidative stress[178, 183]	Nicotine[184, 185] Aldehydes[186–188] Heavy metals[189, 190] PAHs[191] TSNA[192] ROS[193] Furans[194] Phthalates[195]
Waterpipes (Hookah, E-Hookah)	Starbuzz, Tangiers, Al-Fakher tobacco brands*	Fruits, Mint/menthol[66]	Platelet activation[35] Endothelial dysfunction[196–198] coagulation[199]	Nicotine[200] TSNA [200, 201] PAHs[202] Heavy metals[190, 203] TPM[204] CO[205]
Cigars and cigarillo	Black & Mild Swisher Sweets Cohiba	Mint/menthol Fruits sweet[206]	No sufficient data available	Nicotine[207] Heavy metals[167] TSNA[208]
Heat-not-burn tobacco product (Heated tobacco products)	iQos, Plom	Tobacco, menthol, bubble gum and lime[209]	Endothelial dysfunction[210] Platelet function[211, 212] Oxidative stress[211, 212]	Nicotine[47] TSNAs[213] CO[10] Tar[10] TPM[214]
Smokeless tobacco products	Pouches: ZYN, DRYFT, On! Snus: Swedish Snus	Mint[215] Wintergreen[215]	Platelets[216] (no effects) Endothelial effects[217, 218] Coagulation[219] (no effects) Oxidative stress[220]	Nicotine[221] TSNAs [222] PAHs[222] Heavy metals[220]