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. 2022 May 18;20:233. doi: 10.1186/s12951-022-01431-8

Fig. 4.

Fig. 4

Distinct cytotoxic effects of PTX nanoformulations on GC1 PDOs at the transcriptome and cellular levels. A Transcriptome analysis of GC1 PDOs after treatment with Albu-PTX or Lipo-PTX. Differential gene cluster analyses are shown as heatmap. B KEGG pathway analysis of GC1 after treatment with Albu-PTX or Lipo-PTX. C GSEA of GC1 for gene sets that were changed in the Lipo-PTX treatment group versus the Albu-PTX treatment group. Live-Dead staining analysis of GC1 PDOs after treatment with Albu-PTX or Lipo-PTX. Green: live cells; red: dead cells. Scale bar, 50 μm