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. 2022 May 18;20:233. doi: 10.1186/s12951-022-01431-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — In vivo antitumor effects of intratumorally injected PTX nanoformulations in the GC1 PDX model. A Schematic illustration of GC1 PDX construction and the experimental design used in evaluation of the PDX response to intratumoral injection of PTX nanoformulations. B Individual growth kinetics of PDX tumors in different treatment groups (n = 6). C Survival curves of the mice in B. D TUNEL assay results and IHC analysis of Ki-67 expression in different treatment groups. Scale bar, 200 μm. Data in (D) are presented as the means ± s.d. (n = 3), and P values are determined by log-rank (Mantel-Cox) test (C) or one-way ANOVA with Tukey post-hoc test (D). ***P < 0.001 and ****P < 0.0001