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(A) The highly helical structure of CA dimer (PDB code: 5HGL) and a critical ligand-binding pocket (NTD-CTD interface, red dotted line). The pocket formed around H3 and H4 of the CA1NTD (blue), and H8 and H9 of the adjacent CA2CTD (green) accommodates the binding of multiple ligands, including host factors CPSF6 and NUP153, and small molecules PF74 and GS-6207; (B) The chemical structures of PF74 and GS-6207. The figure is generated in PyMOL (www.pymol.org).
