Table 2.
Long-term experiments. Biochemical values in each comparison group at the time of initiation of DKA treatment in the juvenile period, mean (SD)
| HG control | DKA | DKA-minocycline | DKA-TRAM-34 | |
| n=16 | n=16 | n=10 | n=10 | |
| pH* | 7.33 (0.03) | 6.77 (0.16) | 6.92 (0.08) | 6.84 (0.05) |
| Glucose (mg/dL/ mmol/L)† | 568 (127) | 432 (86) | 359 (35) | 445 (151) |
| Sodium (mEq/L) | 134 (4) | 134 (4) | 130 (4) | 132 (11) |
| Bicarbonate (mEq/L)‡ | 29 (3) | 11 (3) | 10 (1) | 9 (2) |
| BUN (mg/dL/mmol/L)§ | 19 (5) | 55 (29) | 26 (5) | 62 (44) |
*p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.
†p<0.01 for pairwise comparisons of all DKA groups versus NG control and HG control versus NG control.
‡ p<0.01 for all pairwise comparisons of DKA groups versus HG control and DKA groups versus NG control.
§p<0.05 for pairwise comparisons of DKA versus NG control and DKA-minocycline veesus NG control.
BUN, blood urea nitrogen; DKA, diabetic ketoacidosis; HG, hyperglycemic; NG, normoglycemic; TRAM-34, triarylmethane-34.