Table 1.
IC50 of the selected compounds in AS, FP, and FRET assays.
| Compound Identification number (CID) | Vendor ID | IC50 AS SARS-CoV-2 (μM) | IC50 FP SARS-CoV-2 (μM) |
IC50 AS MDO2 (μM) | IC50 AS MERS (μM) | IC50 FRET SARS-CoV-2 (μM) |
|---|---|---|---|---|---|---|
| ADP-ribose | 1.5 ± 0.05 | 9.74 ± 0.75 | 0.42 ± 0.05 | 1.25 ± 0.23 | N.D. | |
| Compounds inhibit both AS and FP | ||||||
| 2808616 (1) | GK02919 | 6.2 ± 0.7 | 53.6 ± 7.4 | >300 | 39.6 ± 4.0 | N.D. |
| 2810370 (2) | HTS01833 | 83.0 ± 5.1 | 4.4 ± 0.3 | >300 | >300 | N.D. |
| 50779772 (6) | F594-1001 | 8.5 ± 0.1 | 68.0 ± 29.8 | >300 | >300 | 45 ± 10.9 |
| 146057603 (7) | F594-1011 | 52.9 ± 0.1 | 338 ± 4.9 | >300 | >300 | N.D. |
| 50849069 (10) | Z269-0281 | 26.7 ± 6.5 | 75.2 ± 10.6 | >300 | 181.3 ± 14.4 | N.D. |
| 50848809 (11) | Z269-0215 | 56.9 ± 33.7 | 27.6 ± 11.1 | 174.15 ± 6.6 | 181.8 ± 4.7 | N.D. |
(N.D.): not determined.