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. 2022 May 19;2022(5):CD002118. doi: 10.1002/14651858.CD002118.pub6

2. Blastocyst formation and implantation rate (in day 5 to 6 transfers).

Study Blastocyst formation rate Implantation D2/3 Implantation D5/6 Other
Aziminekoo 2015 22.4% 21/173; 12.1% 22/152; 14.5%  
Brugnon 2010 Not stated 24/52; 46.2% 23/55; 41.8%  
Bungum 2003 55.2% 50/114; 43.9% 44/120; 36.7% 2/61 participants had only 1 blastocyst
Coskun 2000 28% 50/235; 21.3% 52/218; 23.9% 77% participants had at least 1 blastocyst
Devreker 2000 Not stated 1/34; 2.9% 8/19; 42.1%  
Elgindy 2011 97% 71/197; 36% 53/280; 19%  
Emiliani 2003 48% 57/197; 28.9% 50/168; 29.8%  
Fernandez‐Shaw 2015 67.7 % 20/71; 28.1% 36/84; 42.8%  
Fisch 2007 Not stated 11/12; 92% 4/8; 50%  
Frattarelli 2003 Not stated 18/69; 26.1% 23/53; 43.4%  
Gaafar 2015 Not stated Not stated Not stated  
Gardner 1998a 46.5% 64/174; 36.8% 53/95; 55.8% 85% women had at least 2 blastocysts
Hatirnaz 2017 52.6% 45/95; 47.4% 43/95; 45.3%  
Hreinsson 2004 33% 29/139; 20.9% 24/114; 21.1% 2 morula replaced (one implanted). 60% pregnancy rate when top‐quality blasts transferred
Karaki 2002 33% 37/291 12.7% 37/142; 26.1% 9/80 cancelled due to lack of blastocysts (unselected)
Kaser 2017 Not stated 23/56; 41.1% 26/53; 49.1%  
Kaur 2014 Not stated 66/309; 21.4% 102/290; 35.2%  
Kolibianakis 2004 50.7% 96/234; 41.0% 94/226; 41.6%  
Levi‐Setti 2018 Not stated 25.67% 28.37%  
Levitas 2004 43% 4/56; 7.1% 10/24; 4.2% Day 5‐7 26% cancelled due to lack of blastocysts (poor prognosis)
Levron 2002 34.2% 53/137; 38.7% 20/99; 20.2% 6.5% cancelled due to lack of blastocysts (good prognosis)
Livingstone 2002 Not stated      
Motta 1998 Not stated 51/262; 19.5% 36/120; 30.0% 6/58 cycles cancelled D5 no blastocysts
Pantos 2004 44.6% 15.8% 15.8%  
Papanikolaou 2005 Not stated 35/170; 20.6% 59/158; 37.3% 4/158 women had only 1 blast transferred due to lack of availability and 1 had it on request
Papanikolaou 2006 Not stated 38/156; 24% 58/149; 38.9% Number of participants with no embryos available D3: 8 and D5: 11
Rienzi 2002 44.8% 34/96; 35.4% 38/100; 38.0% Good prognosis
Schillaci 2002 60.3% 23/168; 13.7% 26/110; 23.6% Unselected population nil cancellations D5
Singh 2017 Not stated Not stated Not stated  
Ten 2011 Not stated 21/54; 38.9% 26/56; 46.4% Good prognosis
Van der Auwera 2002 44.7% 31/106; 29.2% 41/90; 45.6% 27% cancellation D5 (unselected population)
Yang 2018 Not stated 80/290; 62.1% 22/306; 72.5%