Aziminekoo 2015.

Study characteristics
Methods	Study type: randomised controlled trial in parallel groups Country: Iran
Participants	Number of participants randomised: 118 Age: BS 34.9 and CS 35.1 Number of previous treatments: BS 3.7 and CS 3.1 Infertility duration: BS 10.3 and CS 8.5 years Prognosis: poor prognostic factors Inclusion criteria: infertile women with at least two previous failures of implantation Exclusion criteria: females aged more than 40 years old with severe untreated uterus abnormalities, and couples with severe male factor infertility, such as severe oligospermia
Interventions	BS group: N = 57 CS group (day 3): N = 61 Description of the cycles: Long protocol (down‐regulation with GnRH agonist and stimulation with rFSH) Injected oocytes were transferred to culture dish with cleavage medium (Sydney IVF cleavage medium, Cook Medical) In blastocyst group, on day 3, embryos were transferred to blastocyst medium (Sydney IVF blastocyst medium) for 48 h extended culture. Then, the day 5 embryos (blastocysts) were transferred to uterus. All embryo transfers were performed using the Sydney IVF catheter (K‐JETS‐7019‐SIVF; Cook Medical) To support luteal phase, all participants received progesterone suppository.
Outcomes	Clinical pregnancy rate Multiple pregnancy rate Miscarriage rate Cancellation
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