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. 2022 May 19;2022(5):CD002118. doi: 10.1002/14651858.CD002118.pub6

Kolibianakis 2004.

Study characteristics
Methods
  • Study type: randomised controlled trial in parallel groups

  • Country: Belgium

Participants
  • Number of participants randomised: 460

  • Age: BS 31.5 and CS 31.1 years

  • Number of previous treatments: BS 0.8 and CS 0.7

  • Infertility duration: not stated

  • Prognosis: unselected participants

  • Inclusion criteria: women under 43 years of age and an indication for IVF

  • Exclusion criteria: preimplantation genetic screening and azoospermia.

Interventions
  • BS group: N = 226

  • CS group (day 3): N = 234

  • Description of the cycles:

    • Two ovarian stimulation protocols were used in the present study. Initially, the long protocol (down‐regulation with GnRH agonist and stimulation with rFSH). A combination of GnRH antagonist and recombinant gonadotropins was introduced in turn, and gradually replaced the long agonist protocol.

    • Embryos were cultured in sequential media G1/G2 (Vitrolife, Goethenburg,Sweden).

    • To support luteal phase, all participants received progesterone suppository.

Outcomes Clinical pregnancy rate
Miscarriage rate
Embryo freezing rate
Failure to transfer embryos
Notes Prognosis: mixed unselected