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. 2022 May 18;4(5):e0699. doi: 10.1097/CCE.0000000000000699

Figure 3.

Figure 3.

Surfactant protein D (SPD)−/− mice have diminished cecal Escherichia coli colonization. A, E. coli cultured from cecal culture of homozygote bred SPD+/+ mice (n = 24) and SPD−/− mice (n = 15) (**p < 0.0001, Mann-Whitney). B, E. coli cultured from cecal culture of heterozygote bred, cohoused SPD+/+ (n = 5) mice and SPD−/− mice (n = 12) (p > 0.05, Mann-Whitney). C, E. coli cultured from cecal culture of heterozygote bred, SPD+/+ mice (n = 5) and SPD−/− mice (n = 10) after 7 wk of separation, by genotype (*p < 0.05, Mann-Whitney). D, Post-cecal ligation and puncture (CLP) survival in heterozygote bred, cohoused SPD+/+ mice (n = 12) and SPD−/− mice (n = 14), where SPD−/− mice had exposure to E. coli from the feces of SPD+/+ mice (p = ns, Gehan-Breslow-Wilcoxon). E, Post-CLP survival of homozygote bred SPD+/+ (n = 6) and SPD−/− (n = 9) mice (Gehan-Breslow-Wilcoxon, **p < 0.01) for concurrent recapitulation of the findings in Figure 1A. CFU = colony forming units.