. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: Stat Biopharm Res. 2020 Nov 5;14(2):153–161. doi: 10.1080/19466315.2020.1819403

Table 2:

Summary of simulation results (negative binomial regression) with copy reference control-based imputation.

		Full Data			Imputation
Parameter	True	Mean	SD	MSE	Mean	SD	SE	MSE
n = 200, non-informative censoring
α	1.000	0.9804	0.1374	0.0193	0.9770	0.1719	0.1711	0.0301
β ₀	1.609	1.6050	0.1114	0.0124	1.5986	0.1248	0.1252	0.0157
β ₁	−0.500	−0.3900	0.1602	0.0257	−0.3767	0.1365	0.1353	0.0188
β ₂	0.500	0.4924	0.1627	0.0265	0.5038	0.1875	0.1813	0.0352
n = 400, non-informative censoring
α	1.000	1.0003	0.0976	0.0095	0.9921	0.1219	0.1215	0.0149
β ₀	1.609	1.6070	0.0755	0.0057	1.6159	0.0873	0.0872	0.0077
β ₁	−0.500	−0.3825	0.1105	0.0122	−0.3802	0.0954	0.0946	0.0091
β ₂	0.500	0.4870	0.1134	0.0130	0.4823	0.1279	0.1272	0.0167
n = 200, informative censoring
α	1.000	1.1017	0.1520	0.0335	1.0183	0.1737	0.1804	0.0305
β ₀	1.609	1.4755	0.1170	0.0292	1.3957	0.1349	0.1308	0.0599
β ₁	−0.500	−0.3930	0.1790	0.0320	−0.4016	0.1474	0.1419	0.0218
β ₂	0.500	0.5179	0.1839	0.0341	0.5211	0.2071	0.1920	0.0433
n = 400, informative censoring
α	1.000	1.1051	0.1096	0.0231	1.0331	0.1305	0.1288	0.0181
β ₀	1.609	1.4766	0.0819	0.0219	1.4010	0.0940	0.0923	0.0484
β ₁	−0.500	−0.3870	0.1236	0.0153	−0.3920	0.0997	0.0999	0.0100
β ₂	0.500	0.5139	0.1237	0.0155	0.5203	0.1382	0.1344	0.0195

Mean, sample average of the parameter estimates; SD, sample standard deviation of the parameter estimates; SE, sample average of the standard error estimates; MSE, mean-squared error.