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. 2022 Mar 30;163(6):bqac038. doi: 10.1210/endocr/bqac038

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Ketogenic diet downregulates Leap2 expression in mouse liver. (A) Treatment groups, (B) BW in chow-cohort, (C) Blood glucose levels in chow-cohort, (D) BHB blood levels in chow-cohort, (E) Relative Leap2 expression levels in liver in chow-cohort, (F) Relative Leap2 expression levels in duodenum in chow-cohort (G) Relative Mct1 expression levels in liver in chow-cohort, (H) Relative Mct1 expression levels in duodenum in chow-cohort, (I) Relative Hcar2 expression levels in liver in chow-cohort, (J) BW in HFD-cohort, (K) Blood glucose levels in HFD-cohort, (L) BHB blood levels in HFD-cohort, (M) Relative Leap2 expression levels in liver in HFD-cohort, (N) Relative Leap2 expression levels in duodenum in HFD-cohort, (O) Relative Mct1 expression levels in liver in HFD-cohort, (P) Relative Mct1 expression levels in in duodenum in HFD-cohort, (Q) Relative Hcar2 expression levels in in liver in HFD-cohort. Data were normalized to reference gene Ywhaz and subsequently normalized to either chow or HFD control (E-I and M-Q, respectively). Data were analyzed by unpaired t test (B-I), and one-way ANOVA followed by Tukey post hoc test (J-Q). Group^Chow, n = 7; Group^Chow-KD, n = 7; Group^HFD, n = 10; Group^HFD-KD, n = 9; Group^HFD-Chow n = 9. Outliers were identified and exclusion of outlier did not diverge from the results of the main analysis and result (E, I, M, N, P). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Abbreviations: BHB; beta-hydroxybutyrate, HFD; high-fat diet, Leap2; Liver-expressed antimicrobial peptide 2.