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. Author manuscript; available in PMC: 2023 May 12.
Published in final edited form as: Cell. 2022 May 2;185(10):1630–1645. doi: 10.1016/j.cell.2022.04.004

Figure 2. Development of atherosclerosis lesions.

Figure 2.

Macrophages proliferate in response to M-CSF, and foam cells are engulfed by macrophages, a process known as efferocytosis. SMC transform to a proliferative state, migrate to the endothelial region and secrete collagen to give rise to a “fibrous cap”. SMC can also transform to macrophage-like cells that take up lipid to give rise to foam cells. T and B cells also enter the lesion and interact with other cell types to promote or retard lesion development.