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. Author manuscript; available in PMC: 2022 May 19.
Published in final edited form as: Nat Chem Biol. 2021 May 10;17(9):954–963. doi: 10.1038/s41589-021-00786-7

Extended Data Fig. 1 |. Chemoproteomic approaches to establish Sulfopin’s selectivity.

Extended Data Fig. 1 |

a, Schematic depiction of Covalent Inhibitor Target-Site Identification (CITe-Id) workflow, showing hypothetical results. CiTe-Id identifies Sulfopin-DTB modified sites across the proteome, and profiles competitively labeled cysteine residues following dose-response treatment with Sulfopin in live PATU-8988T cells. b, Schematic depicting the rdTOP-ABPP experimental workflow to assess Sulfopin proteomic selectivity in MDA-MB-231 cells.