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. Author manuscript; available in PMC: 2022 May 19.
Published in final edited form as: Cell Rep. 2019 Nov 26;29(9):2659–2671.e6. doi: 10.1016/j.celrep.2019.10.074

Figure 7. Vitamin D Promotes EPSC Maintenance by Regulating Metabolic Pathways.

Figure 7.

(A) Venn diagram of genes that were regulated by 1,25-(OH)2D3 treatment (top) or MLL1i/1,25-(OH)2D3 treatment (bottom). Genes were selected by FDR % 0.05 and |FC|≥1.5 compared with untreated ESCs.

(B and C) Venn diagram for genes (FDR ≤ 0.05 and |FC| ≥1.5) upregulated (B) or downregulated (C) by MLL1i/Mll1KO, 1,25-(OH)2D3 or MLL1i/1,25-(OH)2D3. Percentage refers to genes in each category versus all genes that changed expression in three scenarios.

(D) GO term analysis for upregulated gene pathways after MLL1i, 1,25-(OH)2D3 or MLL1i/1,25-(OH)2D3 treatment, as indicated on the bottom. The —log10 p value is presented in the heatmap.

(E) GO term analysis for downregulated gene pathways after MLL1i, 1,25-(OH)2D3, or MLL1i/1,25-(OH)2D3 treatment, as indicated on the bottom. The —log10 p value is presented in the heatmap.

See also Figure S7 and Table S4.