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. Author manuscript; available in PMC: 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11;375(6585):eabi6983. doi: 10.1126/science.abi6983

Figure 2: Protein interactome.

Figure 2:

(A) Overall description of the interactome. (B) Unsupervised Markov clustering of the interactome graph. (C) Example of community and core cluster definition for the translocon/EMC community. (D) The complete graph of connections between interactome communities. The density of protein-protein interactions between communities is represented by increased edge width. The numbers of targets included in each community is represented by circles of increasing diameters. (E) Distribution of occurrence in PubMed articles vs. RNA expression for all proteins found within interactome communities. The bottom 10th percentile of publication count (poorly characterized proteins) is highlighted. (F) NHSL1/NSHL2/KIAA1522 are part of the SCAR/WAVE community and share amino-acid sequence homology (right panel). (G) DMXL1/2, WDR7 and ROGDI form the human RAVE complex. Heatmaps represent the interaction stoichiometry of preys (lines) in the pull-downs of specific OpenCell targets (columns). See text for details.