Table 1.

Summary of epidemiologic data for sporadic and hereditary hemangioblastomas

	Sporadic	Hereditary
Proportion of total cases (%)	~70	~30
Mean age of onset (yr)	47	29
Sex (M:F)	1–1.25:1	1–1.25:1
No. of tumors	Single	Multiple
Localization	Cerebellum most common	Higher proportion of extracerebellar sites (e.g. spine)
Molecular alterations	Somatic loss of VHL detected in subset of cases	VHL loss of function with germline mutation and somatic alteration

VHL, von Hippel-Lindau.