Table 4.

Mutational status of PIK3CA in HNSCC

Sample No.	Age at diagnosis (yr)	Sex	Tumor location	Exon	Nucleotide	Codon change	Amino acid change	Type of mutation
PS212	76	Male	Pyriform sinus	9	G1633A	GAG to AAG	E545K	Missense
PS220	62	Female	Pyriform sinus	9	G1633A	GAG to AAG	E545K	Missense
PS243	72	Male	Pyriform sinus	20	A3140G	CAT to CGT	H1047R	Missense
PS251/1	63	Male	Pyriform sinus	20	C3075T	ACC to ACT	T1025T	Silent
OR183	58	Female	Buccal mucosa	20	C3075T	ACC to ACT	T1025T	Silent
OR214	90	Female	Tongue	20	C3075T	ACC to ACT	T1025T	Silent
OR378	79	Female	Gums	20	C3075T	ACC to ACT	T1025T	Silent
OR391	69	Male	Floor of mouth	20	C3075T	ACC to ACT	T1025T	Silent
OR205	79	Female	Lip	20	A3140G	CAT to CGT	H1047R	Missense
OR209	66	Female	Lip	20	A3140G	CAT to CGT	H1047R	Missense

PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; HNSCC, head and neck squamous cell carcinoma.