Table 4.
ROI-based correlations of FA and depressive symptoms, controlling for age and sex
| BDI-II Factor | ROI | Multiple Regression | |
|---|---|---|---|
| p- value | |||
| Dysphoric mood | Fornix (cres) / Stria terminalis R | 0.0070 (0.0032) | 0.037 |
| Loss of interest/pleasure | Splenium of corpus callosum | 0.0262 (0.0126) | 0.048 |
| Somatic | Corticospinal tract L | 0.0121 (0.0056) | 0.041 |
| Superior cerebellar peduncle R | 0.0122 (0.0051) | 0.024 | |
| Cerebral peduncle R | 0.0140 (0.0063) | 0.034 | |
| Anterior corona radiata R | 0.0167 (0.0068) | 0.021 | |
| External capsule R | 0.0137 (0.0052) | 0.014 | |
| External capsule L | 0.0139 (0.0054) | 0.015 | |
| Cingulum (cingulate gyrus) R | 0.0150 (0.0052) | 0.008 | |
| Cingulum (cingulate gyrus) L | 0.0133 (0.0055) | 0.024 | |
| Cingulum (hippocampus) L | 0.0193 (0.0082) | 0.026 | |
| Fornix (cres) / Stria terminalis R | 0.0124 (0.0052) | 0.024 | |
| Superior fronto-occipital fasciculus R | 0.0140 (0.0059) | 0.026 | |
| Superior fronto-occipital fasciculus L | 0.0158 (0.0056) | 0.009 | |
| Tapetum R | 0.0174 (0.0059) | 0.006 | |
| Tapetum L | 0.0150 (0.0046) | 0.003 | |
The subcallosal cingulate cortex (SCC) and its connections have been implicated in the pathophysiology of major depressive disorder (MDD). We used diffusion tensor imaging to examine the MDD-related structural abnormalities underlying depressive symptoms in PD (n=31). SCC (green box) and medial prefrontal cortex (yellow box) connectivity (group averaged red tract) in the left hemisphere was positively correlated with severity of dysphoric mood symptoms, suggesting abnormal SCC connectivity underlies depressive symptoms in both PD and MDD, particularly when depression in PD is dominated by dysphoric mood.