Extended Data Table 3 -.
HLA allele composition in Italian patients with MIS-C compared to children with COVID-19 and healthy children
| Category | Subject # | Predicted Ancestry | HLA class I | HLA Class II | ||||||||
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| A | B | C | DQA1 | DQB1 | DRB1 | DPA1 | DPB1 | DRB3 | DRB4 | |||
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| TO-006 | EUR | *02, *11 | *35; *52 | *04; *12 | *01; *05 | *05; *03 | *01; *11 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| TO-009 | EUR | *02, *02 | *35; *37 | *04; *06 | *01; *04 | *04; *06 | *08; *15 | *01; *01 | *04; *04 | *01; *01 | *03; *03 | |
| TO-010 | EUR | *02; *H | *35; *53 | *04; *04 | *01; *05 | *03; *05 | *11; *14 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| TO-017 | EUR | *02; *24 | *35; *35 | *04; *04 | *01; *05 | *03; *05 | *11; *14 | *01; *01 | *04; *10 | *02; *02 | *03; *03 | |
| MIS-C | PV-006 | EUR | *02; *68 | *35; *35 | *04; *04 | *01; *03 | *03; *05 | *08; *14 | *01; *01 | *04; *13 | *02; *02 | *03; *03 |
| PV-009 | EUR | *32; *24 | *38; *55 | *03; *12 | *03; *05 | *03; *03 | *04; *11 | *01; *01 | *04; *04 | *02; *02 | *01; *03 | |
| TO-001 | EUR | *29; *30 | *44; *53 | *04; *16 | *03; *04 | *03; *04 | *08; *13 | *01; *01 | *03; *04 | *03; *03 | *03; *03 | |
| TO-024 | AFR | *23; *36 | *53; *58 | *03; *04 | *01; *02 | *02; *06 | *07; *13 | *02; *03 | *01; *04 | *03; *03 | *01; *03 | |
| TO-027 | AFR | *02; *30 | *44; *53 | *04; *07 | *02; *05 | *02; *02 | *03; *13 | *02; *02 | *01; *17 | *02; *02 | *03; *03 | |
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| PV-173 | EUR | *03; *68 | *18; *51 | *12; *14 | *05; *06 | *03; *03 | *08; *11 | *01; *01 | *02; *03 | *02; *02 | *03; *03 | |
| PV-172 | EUR | *01; *03 | *08; *35 | *04; *07 | *05; *05 | *02; *02 | *03; *03 | *01; *01 | *02; *14 | *01; *02 | *03; *03 | |
| PV-171 | EUR | *01; *03 | *08; *35 | *04; *07 | *05; *05 | *02; *02 | *03; *03 | *02; *02 | *01; *14 | *01; *02 | *03; *03 | |
| PV-170 | EUR | *24; *68 | *18; *52 | *05; *12 | *01; *05 | *02; *06 | *03; *15 | *01; *02 | *13; *13 | *02; *02 | *03; *03 | |
| PV-167 | EUR | *03; *24 | *44; *55 | *03; *05 | *01; *01 | *05; *05 | *01; *16 | *01; *01 | *04; *04 | *01; *01 | *03; *03 | |
| PV-165 | EUR | *01; *11 | *35; *38 | *04; *12 | *01; *05 | *03; *06 | *11; *15 | *01; *01 | *02; *15 | *02; *02 | *03; *03 | |
| PV-162 | EUR | *24; *26 | *18; *40 | *05; *07 | *01; *05 | *02; *05 | *01; *03 | *01; *02 | *04; *10 | *01; *01 | *03; *03 | |
| PV-161 | EUR | *01; *02 | *18; *44 | *05; *07 | *01; *02 | *02; *05 | *07; *15 | *01; *02 | *02; *14 | *01; *01 | *01; *03 | |
| PV-160 | EUR | *02; *03 | *44; *57 | *05; *18 | *01; *02 | *02; *06 | *07; *15 | *01; *01 | *02; *04 | *01; *01 | *01; *03 | |
| PV-159 | EUR | *01; *03 | *38; *57 | *12; *18 | *01; *01 | *05; *06 | *10; *15 | *01; *01 | *04; *13 | *01; *01 | *03; *03 | |
| PV-150 | EUR | *01; *24 | *35; *51 | *01; *15 | *03; *03 | *03; *03 | *04; *04 | *02; *02 | *13; *14 | *01; *01 | *01; *01 | |
| PV-149 | EUR | *02; *11 | *15; *18 | *01; *12 | *01; *03 | *03; *05 | *09; *15 | *01; *01 | *02; *04 | *01; *01 | *01; *03 | |
| PV-148 | EUR | *01; *25 | *08; *08 | *07; *07 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *02; *04 | *01; *02 | *03; *03 | |
| PV-142 | EUR | *03; *24 | *18; *35 | *04; *12 | *03; *05 | *03; *03 | *04; *11 | *01; *01 | *04; *04 | *02; *02 | *01; *03 | |
| PV-140 | EUR | *02; *32 | *40; *50 | *03; *06 | *02; *02 | *02; *03 | *07; *15 | *02; *02 | *13; *14 | *01; *01 | *01; *01 | |
| PV-139 | EUR | *02; *32 | *40; *50 | *03; *06 | *02; *02 | *02; *03 | *07; *15 | *02; *02 | *13; *14 | *01; *01 | *01; *01 | |
| PV-138 | EUR | *02; *30 | *07; *13 | *06; *07 | *01; *02 | *02; *06 | *07; *15 | *01; *01 | *04; *04 | *01; *01 | *01; *03 | |
| PV-137 | EUR | *02; *30 | *07; *13 | *06; *07 | *01; *02 | *02; *06 | *07; *15 | *01; *01 | *04; *04 | *01; *01 | *01; *03 | |
| PV-136 | EUR | *33; *11 | *14; *35 | *04; *08 | *01; *01 | *05; *05 | *01; *16 | *01; *02 | *04; *10 | *01; *01 | *03; *03 | |
| PV-134 | EUR | *24; *32 | *13; *44 | *04; *06 | *02; *05 | *02; *02 | *03; *07 | *01; *01 | *04; *04 | *01; *01 | *01; *03 | |
| TO-023 | EUR | *24; *24 | *35; *49 | *04; *07 | *03; *05 | *03; *03 | *04; *11 | *01; *01 | *03; *04 | *02; *02 | *01; *03 | |
| TO-022 | EUR | *32; *24 | *07; *49 | *07; *07 | *01; *03 | *03; *05 | *04; *16 | *01; *01 | *02; *04 | *01; *01 | *01; *03 | |
| TO-021 | EUR | *32; *24 | *07; *49 | *07; *07 | *01; *03 | *03; *05 | *04; *16 | *01; *01 | *02; *04 | *01; *01 | *01; *03 | |
| TO-020 | EUR | *01; *32 | *44; *57 | *05; *06 | *02; *05 | *03; *03 | *07; *11 | *01; *01 | *02; *04 | *02; *02 | *01; *03 | |
| TO-019 | EUR | *11; *24 | *39; *51 | *12; *15 | *01; *05 | *03; *05 | *11; *16 | *02; *02 | *14; *17 | *02; *02 | *03; *03 | |
| TO-018 | EUR | *01; *03 | *37; *49 | *07; *06 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *02; *04 | *02; *03 | *03; *03 | |
| PV-123 | EUR | *24; *69 | *13; *55 | *03; *06 | *01; *02 | *02; *05 | *07; *14 | *02; *02 | *17; *17 | *02; *02 | *01; *03 | |
| BS-HS-235 | EUR | *02; *30 | *13; *13 | *06; *06 | *02; *02 | *02; *02 | *07; *15 | *01; *01 | *04; *04 | *01; *01 | *01; *01 | |
| TO-016 | EUR | *26; *68 | *38; *40 | *02; *12 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *02; *04 | *01; *02 | *03; *03 | |
| TO-014 | EUR | *24; *25 | *40; *44 | *05; *15 | *01; *05 | *03; *05 | *11; *14 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| TO-013 | EUR | *32; *68 | *18; *57 | *07; *12 | *01; *02 | *02; *05 | *07; *14 | *01; *02 | *02; *10 | *02; *02 | *01; *03 | |
| pCOVID-19 | TO-012 | EUR | *03; *03 | *07; *35 | *04; *07 | *01; *01 | *05; *05 | *01; *14 | *01; *02 | *04; *05 | *02; *02 | *03; *03 |
| TO-011 | EUR | *32; *68 | *18; *57 | *07; *12 | *01; *02 | *02; *05 | *07; *14 | *01; *02 | *02; *10 | *02; *02 | *01; *03 | |
| TO-008 | EUR | *23; *68 | *35; *49 | *07; *07 | *04; *05 | *03; *04 | *08; *12 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| TO-007 | EUR | *02; *03 | *49; *73 | *07; *15 | *01; *03 | *02; *05 | *01; *04 | *01; *01 | *03; *13 | *01; *01 | *01; *01 | |
| TO-005 | EUR | *02; *24 | *08; *18 | *07; *12 | *01; *05 | *03; *05 | *01; *11 | *01; *02 | *02; *04 | *02; *02 | *03; *03 | |
| TO-004 | EUR | *02; *23 | *41; *44 | *04; *17 | *01; *02 | *02; *06 | *07; *13 | *01; *01 | *02; *02 | *03; *03 | *01; *03 | |
| TO-003 | EUR | *26; *01 | *15; *18 | *03; *06 | *01; *05 | *03; *05 | *11; *16 | *01; *01 | *02; *02 | *02; *02 | *03; *03 | |
| TO-002 | EUR | *02; *32 | *15; *44 | *02; *07 | *01; *01 | *05; *06 | *13; *16 | *01; *01 | *02; *04 | *03; *03 | *03; *03 | |
| PV-031 | EUR | *02; *26 | *39; *52 | *12; *12 | *01; *05 | *03; *06 | *11; *15 | *01; *01 | *02; *04 | *02; *02 | *03; *03 | |
| PV-015 | EUR | *26; *32 | *38; *51 | *02; *12 | *01; *01 | *05; *05 | *01; *16 | *01; *01 | *04; *10 | *01; *01 | *03; *03 | |
| PV-008 | EUR | *03; *11 | *35; *49 | *04; *07 | *01; *02 | *02; *05 | *07; *15 | *01; *01 | *01; *04 | *01; *01 | *01; *03 | |
| PV-007 | EUR | *03; *24 | *51; *57 | *07; *15 | *02; *05 | *03; *03 | *07; *11 | *01; *01 | *03; *04 | *02; *02 | *01; *03 | |
| PV-002 | EUR | *02; *02 | *08; *15 | *03; *07 | *01; *05 | *02; *05 | *03; *14 | *01; *01 | *03; *14 | *02; *02 | *03; *03 | |
| CG-807 | EUR | *01; *02 | *08; *50 | *06; *07 | *02; *05 | *02; *02 | *03; *07 | *01; *01 | *04; *04 | *01; *01 | *01; *03 | |
| PV-156 | AMR | *02; *24 | *39; *40 | *07; *08 | *04; *04 | *03; *04 | *08; *08 | *01; *01 | *04; *04 | *01; *01 | *01; *01 | |
| PV-154 | AMR | *02; *24 | *39; *40 | *07; *08 | *04; *04 | *03; *04 | *08; *08 | *01; *01 | *04; *04 | *01; *01 | *01; *01 | |
| PV-152 | AMR | *01; *24 | *35; *51 | *01; *15 | *03; *03 | *03; *03 | *04; *04 | *02; *02 | *13; *14 | *01; *01 | *01; *01 | |
| PV-144 | AMR | *01; *26 | *15; *40 | *02; *15 | *03; *05 | *03; *03 | *04; *11 | *01; *01 | *03; *04 | *02; *02 | *03; *03 | |
| PV-133 | AMR | *01; *32 | *50; *58 | *07; *17 | *02; *05 | *02; *02 | *03; *07 | *01; *02 | *03; *17 | *01; *01 | *01; *03 | |
| PV-132 | AMR | *32; *01 | *50; *58 | *17; *07 | *02; *05 | *02; *02 | *03; *07 | *01; *02 | *03; *17 | *01; *01 | *01; *03 | |
| PV-130 | AMR | *24; *29 | *45; *45 | *06; *16 | *01; *02 | *02; *05 | *07; *10 | *01; *01 | *04; *17 | *01; *01 | *01; *03 | |
| PV-129 | AMR | *24; *29 | *45; *45 | *06; *16 | *01; *02 | *02; *05 | *07; *10 | *01; *01 | *04; *17 | *01; *01 | *01; *03 | |
| PV-087 | AMR | *02; *34 | *27; *35 | *02; *06 | *01; *01 | *05; *06 | *13; *16 | *01; *01 | *04:*85 | *02; *02 | *03; *03 | |
| TO-015 | AMR | *02; *24 | *44; *51 | *05; *15 | *01; *03 | *03; *06 | *09; *13 | *01; *02 | *04; *05 | *03; *03 | *01; *03 | |
| PV-005 | AMR | *26; *36 | *14; *15 | *02; *08 | *02; *02 | *02; *02 | *07; *07 | *01; *02 | *04; *11 | *01; *01 | *01; *01 | |
| PV-164 | AFR | *03; *03 | *15; *42 | *14; *17 | *02; *05 | *02; *02 | *03; *07 | *02; *02 | *01; *01 | *02; *02 | *01; *03 | |
| PV-127 | AFR | *03; *03 | *53; *53 | *04; *04 | *01; *04 | *03; *06 | *08; *11 | *02; *02 | *01; *01 | *03; *03 | *03; *03 | |
| PV-126 | AFR | *02; *30 | *15; *18 | *14; *18 | *01; *03 | *02; *06 | *09; *15 | *01; *02 | *01; *02 | *01; *01 | *01; *03 | |
| BS-NEW-49 | AFR | *33; *68 | *07; *44 | *04; *15 | *01; *01 | *05; *05 | *01; *11 | *01; *03 | *01; *04 | *02; *02 | *03; *03 | |
| PV-088 | AFR | *02; *30 | *07; *42 | *07; *17 | *01; *05 | *02; *06 | *03; *15 | *02; *03 | *01; *04 | *02; *02 | *03; *03 | |
| PV-158 | SAS | *68; *32 | *35; *35 | *04; *07 | *01; *01 | *05; *06 | *13; *14 | *02; *02 | *13; *17 | *01; *02 | *03; *03 | |
| PV-157 | SAS | *24; *33 | *58; *58 | *03; *03 | *03; *05 | *02; *03 | *03; *04 | *01; *02 | *02; *04 | *02; *02 | *01; *03 | |
| PV-131 | SAS | *68; *02 | *37; *51 | *06; *16 | *01; *01 | *05; *05 | *10; *10 | *01; *01 | *02; *04 | *01; *01 | *03; *03 | |
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| CT-057 | EUR | *01; *02 | *15; *35 | *03; *04 | *02; *05 | *03; *03 | *07; *11 | *01; *02 | *04; *13 | *02; *02 | *01; *03 | |
| CT-014 | EUR | *02; *24 | *18; *35 | *04; *07 | *03; *05 | *03; *03 | *04; *11 | *01; *01 | *02; *04 | *02; *02 | *01; *03 | |
| CT-056 | EUR | *01; *03 | *15; *44 | *07; *16 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *09; *264 | *02; *03 | *03; *03 | |
| CT-055 | EUR | *01; *03 | *49; *51 | *07; *15 | *01; *01 | *05; *06 | *13; *16 | *01; *01 | *04; *04 | *03; *03 | *03; *03 | |
| CT-053 | EUR | *01; *03 | *35; *49 | *07; *12 | *01; *05 | *03; *05 | *11; *14 | *01; *01 | *02; *03 | *02; *02 | *03; *03 | |
| CT-052 | EUR | *01; *01 | *40; *57 | *06; *15 | *01; *01 | *05; *05 | *01; *14 | *01; *02 | *04; *17 | *02; *02 | *03; *03 | |
| CT-050 | EUR | *01; *02 | *08; *18 | *07; *07 | *01; *05 | *02; *05 | *01; *03 | *01; *01 | *02; *04 | *02; *02 | *03; *03 | |
| CT-049 | EUR | *24; *32 | *18; *38 | *07; *12 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *02; *04 | *01; *02 | *03; *03 | |
| CT-048 | EUR | *03; *03 | *18; *40 | *12; *12 | *01; *02 | *02; *05 | *01; *07 | *01; *01 | *04; *04 | *01; *01 | *01; *01 | |
| CT-045 | EUR | *02; *31 | *39; *51 | *12; *15 | *01; *05 | *02; *06 | *03; *13 | *01; *02 | *01; *03 | *01; *02 | *03; *03 | |
| CT-044 | EUR | *24; *24 | *18; *41 | *07; *07 | *01; *05 | *03; *06 | *11; *15 | *01; *01 | *04; *13 | *02; *02 | *03; *03 | |
| CT-043 | EUR | *03; *68 | *07; *38 | *12; *15 | *01; *03 | *03; *06 | *04; *13 | *01; *01 | *03; *04 | *01; *01 | *01; *03 | |
| CT-041 | EUR | *02; *23 | *18; *41 | *12; *17 | *01; *05 | *03; *06 | *11; *13 | *01; *02 | *04; *11 | *01; *02 | *03; *03 | |
| CT-038 | EUR | *02; *24 | *13; *45 | *06; *16 | *01; *05 | *03; *05 | *10; *12 | *01; *03 | *04; *04 | *02; *02 | *03; *03 | |
| CT-037 | EUR | *24; *31 | *27; *44 | *02; *02 | *01; *05 | *03; *06 | *11; *13 | *01; *02 | *04; *10 | *01; *02 | *03; *03 | |
| CT-034 | EUR | *02; *02 | *45; *51 | *14; *16 | *01; *04 | *04; *05 | *08; *11 | *01; *01 | *04; *04 | *03; *03 | *03; *03 | |
| CT-033 | EUR | *02; *11 | *18; *27 | *01; *12 | *05; *05 | *03; *03 | *11; *11 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| CT-028 | EUR | *32; *32 | *15; *57 | *07; *12 | *01; *02 | *02; *06 | *07; *13 | *01; *01 | *02; *02 | *03; *03 | *01; *03 | |
| CT-025 | EUR | *03; *23 | *49; *51 | *07; *14 | *05; *06 | *03; *03 | *08; *11 | *01; *01 | *03; *04 | *02; *02 | *03; *03 | |
| CT-024 | EUR | *01; *23 | *39; *40 | *02; *12 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| CT-022 | EUR | *01; *24 | *08; *51 | *07; *15 | *01; *05 | *02; *06 | *03; *13 | *01; *01 | *02; *02 | *01; *03 | *03; *03 | |
| pHC | CT-021 | EUR | *03; *23 | *18; *39 | *12; *12 | *01; *01 | *05; *06 | *13; *16 | *01; *02 | *01; *04 | *02; *02 | *03; *03 |
| CT-017 | EUR | *01; *23 | *13; *44 | *04; *06 | *02; *02 | *02; *02 | *07; *15 | *02; *02 | *05; *17 | *01; *01 | *01; *01 | |
| CT-016 | EUR | *23; *29 | *44; *49 | *07; *16 | *02; *05 | *02; *03 | *07; *11 | *01; *01 | *01; *02 | *02; *02 | *01; *03 | |
| CT-015 | EUR | *02; *26 | *51; *51 | *01; *05 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *02; *04 | *01; *02 | *03; *03 | |
| CT-013 | EUR | *02; *26 | *18; *44 | *05; *14 | *01; *05 | *02; *06 | *03; *15 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| CT-012 | EUR | *02; *11 | *44; *57 | *05; *06 | *01; *02 | *03; *05 | *07; *11 | *01; *01 | *02; *04 | *02; *02 | *01; *03 | |
| CT-011 | EUR | *11; *25 | *18; *53 | *04; *12 | *01; *01 | *05; *06 | *01; *13 | *02; *02 | *03; *10 | *03; *03 | *03; *03 | |
| CT-010 | EUR | *02; *02 | *15; *18 | *12; *12 | *02; *05 | *02; *03 | *07; *11 | *01; *01 | *02; *04 | *02; *02 | *01; *03 | |
| CT-009 | EUR | *11; *25 | *18; *53 | *04; *12 | *01; *01 | *05; *06 | *01; *13 | *02; *02 | *03; *10 | *03; *03 | *03; *03 | |
| CT-008 | EUR | *02; *24 | *18; *51 | *01; *12 | *05; *05 | *03; *03 | *11; *11 | *01; *01 | *04; *04 | *02; *02 | *03; *03 | |
| CT-004 | EUR | *03; *33 | *14; *27 | *02; *08 | *01; *01 | *05; *06 | *01; *13 | *01; *01 | *02; *04 | *01; *01 | *03; *03 | |
| CT-003 | EUR | *03; *33 | *14; *35 | *04; *08 | *01; *02 | *02; *05 | *01; *07 | *01; *01 | *04; *04 | *01; *01 | *01; *03 | |
| CT-002 | EUR | *01; *24 | *15; *51 | *03; *16 | *01; *05 | *03; *06 | *11; *13 | *01; *01 | *04; *13 | *02; *03 | *03; *03 | |
| CT-001 | EUR | *01; *02 | *13; *51 | *06; *14 | *02; *05 | *02; *03 | *07; *11 | *01; *01 | *04; *04 | *02; *02 | *01; *03 | |
| CT-054 | SAS | *03; *24 | *44; *48 | *07; *08 | *02; *05 | *02; *03 | *07; *11 | *01; *01 | *02; *03 | *02; *02 | *01; *03 | |
| CT-039 | SAS | *11; *11 | *15; *51 | *07; *15 | *01; *03 | *03; *06 | *04; *13 | *01; *01 | *02; *04 | *03; *03 | *01; *03 | |
| CT-030 | SAS | *03; *33 | *44; *44 | *07; *07 | *02; *06 | *02; *03 | *07; *12 | *01; *02 | *02; *269 | *03; *03 | *01; *01 | |
| CT-051 | AFR | *11; *26 | *08; *55 | *03; *07 | *01; *05 | *03; *05 | *11; *14 | *01; *01 | *01; *04 | *02; *02 | *03; *03 | |
| CT-026 | EAS | *33; *34 | *40; *44 | *07; *12 | *01; *02 | *02; *05 | *07; *15 | *02; *02 | *01; *01 | *01; *01 | *01; *03 | |
| CT-036 | AMR | *02; *29 | *13; *15 | *01; *06 | *01; *03 | *03; *06 | *09; *13 | *01; *01 | *04; *04 | *02; *02 | *01; *03 | |
| CT-032 | AMR | *02; *24 | *07; *07 | *07; *15 | *04; *05 | *03; *04 | *08; *11 | *01; *01 | *02; *04 | *02; *02 | *03; *03 | |
| CT-027 | AMR | *03; *32 | *35; *40 | *02; *04 | *01; *03 | *03; *06 | *04; *13 | *01; *01 | *02; *04 | *03; *03 | *01; *03 | |
| CT-018 | AMR | *02; *30 | *18; *42 | *05; *17 | *04; *05 | *02; *04 | *03; *03 | *01; *03 | *04; *04 | *01; *02 | *03; *03 | |
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| Association with HLA- A*02, B*35, C*04 alleles^ (Fisher’s exact t test) | ||||||||||||
| p value | ||||||||||||
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| MIS-C vs. pCOVID-19 | <0.0001 | |||||||||||
| MIS-C vs. pHC | 0.0005 | |||||||||||
| pCOVID-19 vs. pHC | NS | |||||||||||
AFR, Africa; AMR, America; EAS: East Asia; EUR, Europe; MIS-C, multisystem inflammatory syndrome in children; pCOVID-19, pediatric COVID-19; pHC, pediatric healthy controls; SAS, South Asia..
The HLA-A*02, B*35 and C*04 alleles, and subjects sharing a combination of all three these alleles are highlighted in red..
^
Analysis performed on subjects of European ancestry only