TABLE 1.

Cre‐driver and ‐reporter mice

Strain	References	Source information	Key Gene
Atoh1‐Cre	Matei et al. Dev Dyn 234(3):633‐50. 2005	Bernd Fritzsch, University of Iowa Jax 011104 https://www.jax.org/strain/011104	Transgenic construct containing the JQ2‐Atoh1 promoter fragment ligated to the bacteriophage P1 Cre recombinase
Lmx1a‐Cre	Victor V. Chizhikov, Anne G. Lindgren, D. Spencer Currle, Matthew F. Rose, Edwin S. Monuki, Kathleen J. Millen Development 2006 133: 2793–2804; doi: 10.1242/dev.02441	Victor V. Chizhikov, University of Tennessee HSC http://www.informatics.jax.org/allele/key/569853	BAC transgenic construct containing ∼200 kb of the mouse Lmx1a locus with Lmx1a coding sequence replaced by Cre coding sequence
Vglut2‐IRES‐Cre (Slc17a6‐IRES‐Cre)	Vong, Linh, et al. “Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.” Neuron 71.1 (2011): 142–154	Jax 016963 https://www.jax.org/strain/016963	IRES‐Cre inserted downstream of the stop codon of Slc17a6 on chromosome 7
Vgat‐IRES‐Cre (Slc32a1‐IRES‐Cre)	Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011; 71:142−154	Jax 028892 https://www.jax.org/strain/028862	IRES‐Cre inserted after the Slc32a1 stop codon
Ai9(R26‐lsl‐ tdTomato)	Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high‐throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133‐40	Jax 007909 https://www.jax.org/strain/007909	tdTomato (red fluorescent protein) insertion after lox‐STOP‐lox at Rosa26 locus
Ai14(R26‐lsl‐tdTomato) reporter	Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high‐throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133‐40	Jax 007914 https://www.jax.org/strain/007914	Rosa‐CAG‐LSL‐tdTomato‐WPRE targeting vector inserted between exon 1 and 2 of the Gt(ROSA)26Sor locus
R26‐LSL‐L10GFP reporter	Krashes, Michael J., et al. “An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.” Nature 507.7491 (2014): 238	Available from originating investigators http://www.informatics.jax.org/allele/MGI:5559562	Floxed transcription STOP cassette followed by EGFP/Rpl10 fusion reporter gene under control of the CAG promoter targeted to the Gt(ROSA)26Sor locus
Pdyn‐IRES‐Cre	Krashes, Michael J., et al. “An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.” Nature 507.7491 (2014): 238	Jax 027958 https://www.jax.org/strain/027958	IRES‐Cre inserted downstream of the endogenous Pdyn (prodynorphin) gene
Calca‐Cre (Calca‐tm1.1‐Cre‐EGFP)	Carter, M., Soden, M., Zweifel, L. et al. “Genetic identification of a neural circuit that suppresses appetite.” Nature 503, 111−114 (2013)	Richard Palmiter, University of Washington (shared by Andrew Russo, University of Iowa)	Cre:GFP inserted downstream of the endogenous CGRP (calcitonin‐gene‐related‐peptide) gene