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. 2022 May 19;13(5):477. doi: 10.1038/s41419-022-04934-2

Fig. 3. The downregulation of circ-Pank1 in the MN9D cell model alleviates the damage to dopaminergic neurons by reducing the expression of a-syn.

Fig. 3

A, C Western blot analysis of the protein levels of α-syn in the SN of PD model mice treated with rotenone (n = 4). D qRT–PCR to detect the expression of α-syn mRNA in the SN of PD model mice treated with rotenone (n = 4). B–F After si-circ-Pank1 and the corresponding control were transferred to the MN9D cell model treated with rotenone (n = 3), Western blot analysis of the protein level of α-syn (B, E) and qRT–PCR detection of the mRNA expression of α-syn F. Data are presented as mean ± SD. *P < 0.05, **P < 0.01.