Table 1.

Top SNPs with p values below 1E−15 in UKBB GWAS of AD PRS extremes and not associated with AD in the base GWAS.

CHR	Position	Genomic locus	SNP	Nearest gene	MAF	OR [95% CI]	p value
1	50861622	5	rs7553439	HMGB1P45	0.23	0.86 [0.84–0.9]	2.71E−16
2	65053188	31	rs62137344	Y_RNA (SERTAD2, SLC1A4)	0.12	0.82 [0.78–0.86]	7.43E−19
3	50204745	48	rs3774745	SEMA3F	0.47	0.87 [0.85–0.9]	3.85E−21
3	84464459	53	3:84464459_GA_G	AC107025.1	0.42	0.89 [0.86–0.91]	7.41E−16
5	139741370	89	rs717097	SLC4A9	0.47	0.87 [0.85–0.9]	1.33E−20
6	26907831	95	rs9379945	GUSBP2	0.15	1.2 [0.14–0.22]	5.19E−18
6	28750876	95	rs200690674	NOL5BP	0.1	1.26 [0.18–0.28]	8.67E−20
6	28790373	95	rs146924495	LINC01623/XXbac-BPG308K3.5	0.18	1.23 [0.17–0.25]	3.66E−26
6	29379304	95	rs3117190	OR5V1	0.84	0.84 [0.81–0.87]	3.58E−18
6	29604264	95	rs9461540	SUMO2P1	0.13	0.83 [0.79–0.86]	4.62E−18
6	31221299	95*	rs17197839	HLA-C	0.13	0.76 [0.73–0.79]	5.70E−34
6	57121684	103	rs6904307	RAB23	0.11	1.24 [1.19–1.3]	6.18E−21
6	57922673	103	rs6916215	RBBP4P3	0.28	1.15 [1.11–1.18]	3.28E−16
6	58677437	103	rs2693062	RP11-143A22.1/AL445250.1	0.33	0.84 [0.82–0.87]	1.08E−27
6	62101394	104	rs62425025	AL356131.1	0.42	1.16 [1.12–1.19]	3.86E−22
6	63162857	104	rs9360446	RP11-448N11.1	0.34	0.86 [0.83–0.89]	2.35E−22
6	63820771	104	6:63820771_AC_A	RP11-184C23.1	0.2	1.19 [1.14–1.23 ]	2.13E−20
7	99471072	128	rs2099446	CYP3A52P	0.46	0.89 [0.86–0.91]	6.95E−16
8	42667432	137	rs62515894	CHRNA6	0.06	1.31 [1.23–1.4]	6.51E−17
9	93391288	150	rs183428791	DIRAS2	0.06	1.28 [1.21–1.36]	1.79E−16
11	47197153	167	rs75290815	ARFGAP2	0.07	1.32 [1.24–1.4]	8.66E−21
11	48346996	167	rs12794960	OR4C3	0.16	0.79 [0.76–0.83]	3.93E−30
11	48472051	167	rs61915439	OR4C9P	0.07	1.29 [1.21–1.36]	7.62E−18
11	48709133	167	rs75184591	OR4A44P	0.36	1.23 [1.19–1.27]	2.03E−40
11	50189874	167	11:50189874_CAA_C	RP11-347H15.6	0.82	0.79 [0.76–0.82]	8.50E−33
11	50468801	167	rs1813937	RP11-574M7.2	0.78	1.28 [1.23–1.32]	6.15E−42
11	51253295	167	rs4312050	AC110283.1	0.16	0.82 [0.79–0.86]	7.15E−22
11	51476467	167	rs4515954	OR4C7P	0.17	1.23 [1.19–1.28]	2.35E−26
11	54892370	168	rs58904316	TRIM48	0.17	1.24 [1.19–1.29]	2.44E−26
11	55567256	168	rs72918199	OR5D14	0.06	0.73 [0.68–0.77]	2.45E−23
12	34454301	177	rs7314457	RP13-7D7.1/AK6P1	0.54	1.16 [1.13–1.2]	3.47E−24
12	38666013	178	rs10880819	Y_RNA (ALG10B)	0.46	0.86 [0.83–0.88]	5.48E−25
12	122028904	187	rs28507431	RP13-941N14.1	0.12	1.21 [1.16–1.26]	8.09E−17
13	52496060	190	rs7988558	ATP7B	0.04	1.27 [1.2–1.34]	8.99E−19
13	52862570	190	rs9535966	TPTE2P2	0.05	1.55 [1.45–1.65]	1.11E−36
15	63760569	205	rs4984289	AC007950.1	0.44	1.13 [1.1–1.16]	1.79E−16
15	76772062	208	rs2469249	SCAPER	0.27	0.85 [0.82–0.88]	5.26E−23
16	70676478	217	rs12598456	IL34	0.35	1.16 [1.12–1.19]	2.52E−21
16	70728477	217	rs3785425	VAC14	0.07	1.3 [1.22–1.37]	4.63E−19
17	44257788	229	rs2696697	KANSL1	0.23	0.87 [0.84–0.9]	5.08E−16
19	44522357	239	rs73035978	ZNF230	0.11	1.25 [1.19–1.31]	3.70E−21
19	45235700	239	rs74607435	snoZ6	0.05	0.74 [0.69–0.79]	2.23E−19
19	45938019	239	rs143008566	ERCC1	0.05	0.73 [0.68–0.78]	1.07E−18
19	46049982	239	rs10422253	OPA3	0.78	1.21 [1.16–1.25]	3.35E−25
19	46165082	239	rs112972879	GIPR	0.37	1.16 [1.13–1.2]	3.47E−22
19	46428653	239	rs9789319	NOVA2	0.5	1.14 [1.11–1.17]	1.63E−18
22	41587556	244	rs9607782	EP300-AS1/RP1-85F18.5	0.25	1.16 [1.12–1.2]	3.14E−18