Table 3.
PheWAS results for AD PRS extremes.
| UKBB trait | APOE | Excl. APOE | ||
|---|---|---|---|---|
| β (95% CI) | p value | β (95% CI) | p value | |
| Illnesses of mother: Alzheimer's disease/dementia | 4.41 (4.29, 4.54) | 1 × 10–150* | 4.37 (4.25, 4.50) | 1 × 10–150* |
| Illnesses of father: Alzheimer's disease/dementia | 3.96 (3.79, 4.13) | 1 × 10–150* | 3.95 (3.79, 4.12) | 1 × 10–150* |
| Mother still alive | − 0.51 (− 0.55, − 0.46) | 3.42 × 10–94 | − 0.51 (− 0.55, − 0.46) | 3.42 × 10–94 |
| Father still alive | − 0.51 (− 0.57, − 0.45) | 1.44 × 10–65 | − 0.52 (− 0.57, − 0.46) | 4.24 × 10–66 |
| Alzheimer's disease, unspecified | 3.22 (2.69, 3.86) | 9.7 × 10–28 | 2.89 (2.42, 3.43) | 3.74 × 10–29 |
| Unspecified dementia** | 2.00 (1.59, 2.45) | 5.72 × 10–20 | – | – |
| Illnesses of siblings: Alzheimer's disease/dementia | 1.21 (0.95, 1.48) | 9.85 × 10–19 | 1.10 (0.83, 1.36) | 4.36 × 10–16 |
| Parkinson’s disease in mother | 0.51 (0.36, 0.66) | 9.61 × 10–11 | 0.45 (0.30, 0.60) | 5.69 × 10–9 |
| Tendency to fall, not elsewhere classified | 0.54 (0.32, 0.76) | 1.12 × 10–6 | 0.54 (0.32, 0.76) | 1.45 × 10–6 |
| Ginkgo forte tablet | 0.58 (0.34, 0.83) | 2.24 × 10–6 | 0.50 (0.27, 0.74) | 3.20 × 10–5 |
| Unspecified disorientation** | 0.55 (0.32, 0.78) | 3.07 × 10–6 | – | – |
| Faecal incontinence | 0.58 (0.31, 0.85) | 2.51 × 10–5 | 0.57 (0.30, 0.85) | 4.67 × 10–5 |
Shown are results with adjusted p value ≤ 4.3 × 10–5 and β ≥ |0.5|. APOE indicates the PheWAS using individuals from the PRS extremes when APOE was included; Excl. APOE indicates PheWAS using individuals in the PRS extremes when the APOE locus was excluded from the PRS analysis (see “Methods”).
*p value was too significant, and software output was zero—to plot these values (Fig. 6), we attributed a p value of 1 × 10–150.
**Traits were excluded from PheWAS analysis using individuals from the PRS calculated without APOE due to lack of representation.