Table 4.
Overview MG-ADL, MG-QoL15, HADS, CFQ, ESSI-D and subgroups
| Parameter | All | Men | Women | gMG | oMG | Refractory MG | Ach-R-Abs pos MG | Musk-Abs pos MG | Thym-ectomy | EOMG | LOMG |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
n (missing) % |
1660 (0) 100 |
725 (4) 43.8 |
931 (4) 56.2 |
1127 (41) 69.6 |
345 (41) 21.3 | 228 (200) 15.6 | 837 (41) 51.7 |
82 (41) 5.1 |
743 (43) 45.9 | 176 (11) 10.7 | 1473 (11) 89.3 |
|
MG-ADL Median (IQR) |
4 (1/6) |
3 (1/5) |
4 (7/12) |
4 (2/7) |
2 (1/4) |
7 (4/10) |
3 (1/6) |
5 (2.25/7) |
3 (1/6) |
3 (1/6) |
4 (2/6) |
| p values | – | < 0.00 | < 0.00 | < 0.00 | < 0.00 | < 0.00 | 0.009 | 0.047 | 0.292 | ||
|
MG-QoL15 Median (IQR) |
12 (4/25) |
9 (3/21) |
15 (5/28) |
16 (5/28) |
6 (2/14) |
29 (19/38) |
11 (3/23) |
16 (8/25) |
11 (3/24) |
12 (3/28) |
12 (4/24) |
| p values | – | < 0.00 | < 0.00 | < 0.00 | < 0.00 | < 0.00 | 0.072 | 0.018 | 0.523 | ||
|
HADS Median (IQR) |
10 (5/17) |
9 (4/15) |
11 (6/18) |
11 (6/18) |
8 (4/13) |
12 (8/19) |
9 (5/15) |
10 (5/18) |
9 (5/17) |
10 (5/17) |
10 (5/17) |
| p values | – | < 0.00 | < 0.00 | < 0.00 | < 0.00 | 0.018 | 0.313 | 0.119 | 0.995 | ||
|
HADS-A ≥ 8 p n (%) |
520 (32.5) | 179 (25.5) | 339 (37.9) | 393 (36.1) |
78 (23.2) |
86 (38.4) |
234 (28.4) |
26 (33.8) |
229 (31.6) |
64 (37.2) |
452 (31.9) |
|
HADS-D ≥ 8 p n (%) |
446 (27.9) | 184 (26.1) | 260 (29.2) | 347 (31.9) |
57 (16.8) |
84 (36.8) |
191 (23.4) |
24 (30.8) |
177 (24.5) |
40 (23.1) |
402 (28.4) |
| CFQ sum (Likert) Median (IQR) |
17 (12/21) |
16 (12/21) |
17 (12/22) |
18 (13/22) |
14 (11/18) |
21 (17/25) |
16 (12/21) |
19 (13/23) |
16 (12/21) |
16 (12/21) |
17 (12/22) |
| p values | – | 0.002 | < 0.00 | < 0.00 | < 0.00 | < 0.00 | 0.029 | 0.002 | 0.187 | ||
|
CFQ ≥ 4 (Binary) n (%) |
989 (66.7) | 426 (63.3) | 560 (69.4) | 728 (72.5) | 161 (50.8) |
183 (80.3) |
483 (63.9) |
55 (71.4) |
424 (63.6) | 103 (63.2) |
880 (67.1) |
|
ESSI-D ≤ 18 p n (%) |
343 (22.7) | 102 (15.9) | 241 (27.9) | 253 (24.4) |
55 (17.6) |
60 (26.3) |
156 (20.2) |
9 (11.8) |
151 (21.8) |
42 (24.0) |
300 (22.6) |
| p values | – | < 0.00 | 0.041 | 0.041 | 0.122 | 0.045 | 0.043 | 0.503 | 0.687 | ||
gMG generalized myasthenia gravis, oMG Ocular MG, EOMG Early Onset Myasthenia Gravis (≤ 45 years old), LOMG Late onset myasthenia gravis (> 45 years old), MG-Qol15 Myasthenia gravis quality of life, MG-ADL Myasthenia gravis activities of daily living profile, CFQ-11 Chalder Fatigue scale, ESSI-D ENRICHED Social Support Inventory, HADS-D Hospital anxiety and depression scale; p values indicate significance level or between men and women, or EOMG and LOMG or otherwise in the specific domain (e.g. gMG or Thymectomy) yes/no
significant p values (<0.05) are printed in bold