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. 2022 May 19;12:8398. doi: 10.1038/s41598-022-12594-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analysis of differentially expressed genes (DEGs) in Pcbp1-knockdown Th1 cells and control Th1 cells. (A) Hierarchical clustering heat map showed correlation between Pcbp1-knockdown and control samples based on FPKM value of all expression genes. (B) Volcano plot showed all DEGs between Pcbp1-knockdown and control samples with edgeR. FDR < 0.05 and FC (fold change) ≥ 2 or ≤ 0.5. (C) Hierarchical clustering heat map showed expression levels of all DEGs. (D) Bar plot exhibited the most enriched GO biological process results of the up-regulated DEGs, that making use of analyses by Metascape. (E) Bar plot exhibited the most enriched GO biological process results of the down-regulated DEGs, that making use of analyses by Metascape.