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. 2022 May 19;12:8433. doi: 10.1038/s41598-022-12423-x

Table 1.

Aggregation, %4-SO3 levels and the corresponding in vitro potency for the top three clones.

CAP256V2LS clone Aggregation % (n = 4) 4-SO3% (n = 4) %RP Neutralization efficiency IC80
A03349M1_VRC4A Du156.12 MI369 SVA.MLV
198 5.7 ± 0.5 54.7 ± 5.3 70 0.093 0.019 0.014  > 50
344 4.9 ± 0.8 58.1 ± 1.8 84 0.059 0.012 0.010  > 50
386 2.6 ± 0.1 87.0 ± 0.3 99 0.025 0.009 0.007  > 50

(%RP, a single value from the curve, is normalized against an interim CAP256V2LS reference standard. Neutralization efficiency IC80 is a single value derived from interpolation of 80% signal reduction on a 10 point serially diluted point curve fit via 5-PL non-regression analysis).