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. 2022 May 19;12:8422. doi: 10.1038/s41598-022-12548-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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KL gene expression and epigenetic regulation in PBCCs of CVD and non-CVD subjects. (A) Relative gene expression levels of KL locus, (B) methylation levels of 11 CpG positions (red) in the − 648 and − 560 regions (bold) of KL gene promoter (lowercase “t” represents unmethylated cytosines after conversion with sodium bisulfite), (C) relative gene expression levels of DNMT1 and DNMT3A loci. a.u.: arbitrary units. Bars and range represent median and IQR (A and C) or mean and SEM (B). **: P < 0.01; ****: P < 0.0001.