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. 2022 May 19;13:2785. doi: 10.1038/s41467-022-30466-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Incidence of peripheral nervous system tumors in NF1 patients harboring the c.5425 C > T NF1 germline mutation. pNF: plexiform neurofibroma; (a)⁴⁴, (b)⁴⁵, (c)⁴⁰. B Representative gross images (bright field) of spinal cords from 6-month-old Nf1^f/neo; Hoxb7-Cre (n = 16), Nf1^f/f; Hoxb7-Cre (n = 13), and Nf1^f/1809 ; Hoxb7-Cre (n = 52) mice, showing (C) enlarged DRG (red asterisks) in Nf1^f/neo; Hoxb7-Cre (n = 17; P < 0.0001) and Nf1^f/f; Hoxb7-Cre mice (n = 17; P = 0.0313), but not in Nf1^f/1809 ; Hoxb7-Cre mice (n = 17). Scale bars: 1 mm. The number of mice that formed pNFs is also shown in the top panels in (B). D, E Representative (D) H + E staining, GAP43, Factor XIIIa and CD34 staining, and (E) SOX10 and S100β, immunostaining. n = 4 for all groups. F, G Quantification of SOX10⁺ (n = 3 for all groups; Nf1^f/neo; Hoxb7-Cre, P = 0.0028; Nf1^f/f; Hoxb7-Cre, P = 0.0022) and DAPI⁺ cells (Nf1^f/neo; Hoxb7-Cre, n = 5, P = 0.0028; Nf1^f/f; Hoxb7-Cre, n = 5, P = 0.0067; Nf1^+/1809; Hoxb7-Cre, n = 4) in DRGs. Scale bars, 50 µm. Data are presented as the mean ± SEM. One-way ANOVA with Tukey’s test for multiple comparison. Source data are provided as a Source Data file.