Figure 3.

Murine BMDC cytokine (CK) and chemokine (CC) profiles after LPS exposure determined by multiplex assay. BMDCs from WT and TNF-KO mice were exposed to LPS for 24 hours (N = 8 for each group). Dark grey and blue circles represent the CK or CC level from WT and TNF-KO BMDCs, respectively; light grey and light blue circles show the CK and CC levels after LPS exposure. (A) CK and CC were increased in the TNF-KO BMDCs. (B) CK and CC were decreased in the TNF-KO BMDCs. (C) There was no effect in CK and CC secretion mediated by LPS stimulation. ^∗/+/#P < .05, ^∗∗/++/##P < .01, and ^{∗∗∗/+++/}P < .001. ∗WT versus WT+LPS; ⁺TNF-KO versus TNF-KO +LPS; ^#WT+LPS versus TNF-KO +LPS. G-CSF, granulocyte colony-stimulating factor; KC, keratinocyte-derived chemokine.