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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Invest Dermatol. 2021 Nov 20;142(6):1597–1606.e9. doi: 10.1016/j.jid.2021.10.025

Figure 1: β-catistab leads to inducible and reversible dermal remodeling in mice.

Figure 1:

a, Transgenes in doxycycline-inducible/reversible β-catenin (β-catistab) dermal fibrosis model. b, Fibrosis progression in Masson’s trichrome stained control (top) and β-catistab (bottom) dermis; black and blue bars indicate dermal and DWAT thickness; scale bar=200μm. c, Quantification of average dorsal dermal and DWAT thickness/mouse (n=6–11). d, Indirect immunofluorescence of PLIN1 (green) and CHP stain (red) in control and 10d β-catistab DWAT; quantification of area of PLIN1+ vesicles, 50/mouse (n=9) and relative corrected fluorescence CHP intensity in DWAT; scale bar=25μm. e, Quantification of avg collagen high density matrix (HDM)/40x field/mouse with HDM mask (n=4–9).