Figure 1.

Lpar5 loss induces inflammation in the intestine with epithelial damage. (A) Lpar5^f/f and Lpar5^f/f;RosaCre^ERT mice were administered TAM (40 mg/kg/d) for 5 days and body weights were determined. Initial body weight of each group was set at 100%. n = 3. All data are presented as mean ± SD. ∗P < .05, ∗∗∗P < .01 compared with Lpar5^f/f mice by 1-way analysis of variance with Tukey’s multiple comparison test. Representative of 3 experiments. (B) The representative appearances of the abdomen of TAM-treated Lpar5^f/f and Lpar5^KO mice on day 11 are shown. Bottom panel shows typical appearance of the gastrointestinal tract of Lpar5^KO and Lapr5^f/f mice. (C) Hematoxylin and eosin–stained images of the small intestine and colon of Lpar5^f/f mice. (D) Representative sections from the small intestine and colon of Lpar5^KO mice on day 8 and 11. Scale bar = 200 μm.