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. 2021 Jun 29;71(6):1053–1061. doi: 10.1136/gutjnl-2020-323906

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Replication of GERD and BE association for the genome-wide significant loci from MTAG analysis on GERD and BE in the 23andMe cohort. A refers to the findings for GERD; (B) for BE. Data points that are shaded in blue are those that have a Bonferroni corrected p value below 0.05/88 for GERD and 0.05/17 for BE. Both the x- and y-axes represent log(OR) for GERD/BE and points are plotted with error bars representing one SE. Most of our GERD and BE loci showed strong evidence of being replicated, although the estimated effect size for GERD/BE in the 23andMe cohort were on average smaller than those estimated in the MTAG analysis (slope ~0.5 for both traits). BE, Barrett’s oesophagus; GERD, gastro-oesophageal reflux disease; MTAG, multitrait analysis of genome-wide association studies, SNP, single nucleotide polymorphism.