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. 2021 Jun 29;71(6):1053–1061. doi: 10.1136/gutjnl-2020-323906

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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MAGMA gene-based tissue enrichment analysis for categorised functional and non-functional GERD gene sets on 53 human tissues. The dotted line represents the Bonferroni corrected significance threshold. While both the obesity-driven and neuropsychiatric-driven GERD genes were differentially expressed in brain tissues, only the regulation of gene expression in oesophageal tissues were detected from the obesity GERD gene set. Another observation is that the pattern of regulation is more pleiotropic across tissues for the obesity GERD set, consistent with the complex architecture of adiposity. The results for up-ward and down-ward regulation of gene expression can be viewed in online supplemental materials. GERD, gastro-oesophageal reflux disease