Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 29;71(6):1053–1061. doi: 10.1136/gutjnl-2020-323906

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Estimation of the genetic association between GERD and BE/EA, stratified by genetic GERD subtypes. Each of the slopes represents the estimated magnitude of association between per unit increase in log(OR) of GERD on log(OR) of BE/OA, for all GERD loci (line in blue), obesity-driven GERD loci (line and points in green), and neuropsychiatric-driven GERD loci (line and points in orange) using an inverse variance weighted regression model. Cochran Q statistics indicated strong heterogeneity in the overall all-GERD estimate (p<0.001). In the stratified analysis, it becomes apparent that the overall estimate was primarily driven by the much stronger effect sizes from the obesity-driven GERD loci subset. BE, Barrett’s oesophagus (or Barrett’s esophagus); EA, oesophageal adenocarcinoma (or esophageal adenocarcinoma); GERD, gastro-oesophageal reflux disease; MTAG, multitraitanalysis of GWAS; SNP, single nucleotide polymorphism.