Table 1.

Baseline characteristics, stratified by genetic risk category

	Mutation carriers (n=165)	FPC kindreds (n=201)	P value
Age, mean (SD), years	52 (9.6)	56 (9.8)	<0.001
Male sex, n (%)	73 (44)	84 (42)	0.64
BMI, median (IQR)	25 (4.5)	25 (5)	0.46
Gene mutation, n (%)			–
CDKN2A p16	96 (58)	–	–
BRCA2 + ≥2 blood relatives with PDAC	45 (27)	–	–
BRCA2 + ≥1 FDR with PDAC	25	–	–
BRCA2 + ≥1 SDR with PDAC but no FDR with PDAC	9	–	–
BRCA2 without FDR or SDR with PDAC	11	–	–
BRCA1 + ≥2 blood relatives with PDAC	7 (4)	–	–
BRCA1 + ≥1 FDR with PDAC	6	–	–
BRCA1 + ≥1 SDR with PDAC but no FDR with PDAC	1	–	–
PALB2 + 3 blood relatives with PDAC	2 (1)	–	–
STK11/LKB1	9 (6)	–	–
TP53 + 2 blood relatives with PDAC	5 (3)	–	–
TP53 + ≥1 FDR with PDAC	2	–	–
TP53 + ≥1 SDR with PDAC but no FDR with PDAC	3	–	–
ATM + 3 FDR with PDAC	1 (1)	–	–
Total number of any degree blood relatives with PDAC, n (%)			<0.001
0	32 (19)	–	–
1	24 (15)	–	–
2	49 (30)	104 (52)	–
3 or more	56 (34)	96 (48)	–
Age youngest blood relative with PDAC, median (IQR), years	49 (16)	56 (15)	<0.001
Blood relative with PDAC <50 years of age, n (%)	65 (39)	58 (29)	<0.001
Personal history of non-pancreatic malignancy, n (%)	81 (49)	24 (12)	<0.001
Personal history of diabetes mellitus, n (%)	3 (2)	13 (7)	0.03
Personal history of acute pancreatitis, n (%)	0 (0)	7 (4)	0.02
Smoking, n (%)			0.32
Never	78 (47)	101 (50)	–
Former	68 (41)	67 (33)	–
Current	17 (10)	31 (15)	–
Alcohol use, n (%)			0.88
Never	39 (24)	42 (21)	–
Former	7 (4)	11 (6)	–
Current	116 (70)	145 (72)	–

By definition, FPC kindreds do not carry any of the known PDAC susceptibility gene mutations and have two or more blood relatives affected with PDAC. For the total number of blood relatives with PDAC, smoking and alcohol use, percentages may not add up to 100% because of missing data in up to 2% of participants.

FDR, first-degree blood relative; FPC, familial pancreatic cancer; PDAC, pancreatic ductal adenocarcinoma; SDR, second-degree blood relative.