Figure 1.

†Non-smoking men 18–45 years, baseline SCr <1.3 mg/dL and CRP <10 mg/L. ‡Cystatin C-based eGFR as this better reflects renal filtration and elimination of small proteins,³⁹ something which is considered in a planned substudy using this material. *Those with normal (134–147 mmol/L) serum sodium levels in the first analysed batch were included to minimise potential influence of a previously reported mixing problem.⁴⁰ Four selected cases were affected by this (sodium 131–133 mmol/L in the first aliquot analysis), these were included. CRP, C reactive protein; eGFR, estimated glomerular filtration rate; SCr, serum creatinine.