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. 2022 May 19;13:2770. doi: 10.1038/s41467-022-30430-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Structural comparison of SUR1 TMD0 between the closed state (gray) and the pre-open state (colored) of H175K_cryo-EM. b Close-up view of the interaction between βA of Kir6.2 and SUR1-ICL1 boxed in (a). Putative hydrogen bondings are shown as dashes. c, d Bottom view of the structural arrangement of the K_ATP complex during channel opening. Cα positions of K67 on IH of Kir6.2, K205 on ABLOS of SUR1, and K397 on M7 of SUR1 are shown as spheres. Distances of marker atoms in the pre-open state (colored) and the closed state (gray) are shown in (c, d), respectively.