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. 2022 May 19;13:2770. doi: 10.1038/s41467-022-30430-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–c Side view of the cartoon model of the K_ATP channel. For simplicity, a pair of Kir6 subunits and one SUR2 subunit are shown. Kir6, TMD0, TMD1-NBD1, TMD2-NBD2, Mg²⁺, ATP, ADP, insulin secretagogue (IS), and K_ATP opener (KCO) are colored in green, yellow, pink, blue, dark green, cyan, orange, purple, and red, respectively. The flexible KNtp in the Mg-nucleotide and K_ATP opener-bound state is outlined by dashed lines.