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. 2022 May 19;13:2783. doi: 10.1038/s41467-022-30452-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Simulation of voltage-clamp of AVL in the wild type (left panel) and the exp-2(lf) mutant (right panel). Top: voltage-clamp steps used in numerical simulation: holding potential is −60 mV, each step is 500 ms long in 10 mV increment. Inserts: zoomed-in view of currents from 0 to ~60 ms after returning to holding potential from serial voltage-clamp steps. b Current-voltage (I–V) relationships of normalized simulated repolarization-activated currents for WT (black squares), exp-2(lf) (red triangles), and exp-2(gf) (blue circles). WT and exp-2(gf) IV curves were fitted with Boltzmann functions (color-matching curves). c Representative action potential modeling simulations for wild-type AVL. Top: current-injection steps used in numerical simulation: each step is 5 s long in 2 pA increment. d, e Representative action potential simulations for exp-2(lf) and exp-2(gf) mutants under the same series of current-injection steps to wild-type AVL.