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. 2022 May 19;5:482. doi: 10.1038/s42003-022-03435-4

Fig. 1. Hippocampal depletion of mH2A1 impairs memory more than the depletion of mH2A2.

Fig. 1

a Validation of mH2A1 (encoded by H2afy gene) and mH2A2 (encoded by H2afy2 gene) depletion in the mouse hippocampus. b During the fear memory training session, all mice show increased freezing after receiving shock, suggesting that learning has occurred in all groups. c Depletion of mH2A1, but not of mH2A2, impairs recall of fear memory 24 h after training (N: shScr = 35, shH2afy = 24, shH2afy2 = 18). d mH2A1 depletion does not affect locomotor activity (N = 10/group). e mH2A1 and mH2A2 depletion each impair memory for Object in Place, but the impairment is greater in mH2A-1 than in mH2A2-depleted mice (n: shScr = 16, shH2afy = 17, shH2afy2 = 18). Data are shown as mean ± SEM. (ns p > 0.05, *p < 0.05).