Table 4.

Average age at kidney failure in males with pathogenic COL4A5 variants in LOVD in 2021 compared with 2016.

	Up to 2016 (n = 1,168) (7)	2021 (n = 35)	OR (95%CI), P-value
Missense	504 (43%)	20 (57%)	OR = 0.57 (0.29–1.12), p = 0.10
Non-missense (severe)	664 (57%)	15 (43%)
Ave age at kidney failure	24.4 ± 7.8 years	29.2 ± 14.6 years	p = 0.0026

Relatively more missense (non-severe) variants were detected in 2021 which was consistent with the later age at onset of kidney failure. This may be because families with very severe disease had already been identified.