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. 2022 May 6;13:897413. doi: 10.3389/fimmu.2022.897413

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Copyright © 2022 Maciejczyk, Nesterowicz, Zalewska, Biedrzycki, Gerreth, Hojan and Gerreth

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biochemical reactions occurring in the stroke brain during ischemia and reperfusion. Xanthine oxidase (XO) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid (UA), generating high amounts of superoxide radicals and hydrogen peroxide (H₂O₂).