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. 2022 May 6;13:897413. doi: 10.3389/fimmu.2022.897413

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Copyright © 2022 Maciejczyk, Nesterowicz, Zalewska, Biedrzycki, Gerreth, Hojan and Gerreth

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between salivary XO specific activity and cognitive function in ACE III scale (A), correlations between XO specific activity and several parameters of ACE III score (B); results of ROC analysis for salivary XO specific activity in relation to cognitive function status in ACE III scale in NWS (C–F). ACE III, Addenbrooke’s Cognitive Examination III; mild CI, mild cognitive impairment; moderate CI, moderate cognitive impairment; NWS, non-stimulated whole saliva; XO, xanthine oxidase. Differences statistically significant at ****p < 0.0001. ns, non significance.