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. 2022 May 6;13:897413. doi: 10.3389/fimmu.2022.897413

Table 5.

Multiple regression analysis of salivary ischemia biomarkers in all involved objects.

NWS SWS
XO activity XO specific activity XO output H2O2 concentration UA concentration XO activity XO specific activity XO output H2O2 concentration UA concentration
β1: stroke type Estimate 8.42 16.45 4.21 202.1 21.66 -0.008267 2.015 1.044 20.13 -13.56
95% CI 2.49 - 14.35 8.67 - 24.23 0.47 - 7.95 137.2 - 267.1 0.09 - 43.23 -6.706 - 6.689 -11.4 - 15.43 -3.38 - 5.47 -55.59 - 95.85 -31.62 - 4.5
p-Value 0.0074 0.0002 0.0291 < 0.0001 0.0491 0.998 0.7589 0.6302 0.5877 0.1341
β2: ACE III Estimate -0.02829 -0.2998 0.003936 1.435 -0.1792 -0.019 -0.03557 0.009605 -0.54 -0.4134
95% CI -0.19 - 0.14 -0.52 - -0.07 -0.1 - 0.11 -0.41 - 3.28 -0.79 - 0.43 -0.24 - 0.21 -0.48 - 0.41 -0.13 - 0.15 -3.07 - 1.99 -1.01 - 0.19
p-Value 0.7317 0.0101 0.9397 0.122 0.5517 0.8623 0.8712 0.8944 0.6634 0.1706
β3: BI Estimate -0.3106 -1.223 -0.4194 -10.09 -3.855 -0.4503 0.4518 -0.2671 3.151 -2.186
95% CI -1.38 - 0.76 -2.63 - 0.18 -1.09 - 0.25 -21.83 - 1.64 -7.75 - 0.04 -1.67 - 0.76 -1.99 - 2.89 -1.07 - 0.54 -10.63 - 16.93 -5.48 - 1.1
p-Value 0.5542 0.0848 0.212 0.0884 0.0522 0.4526 0.7055 0.4994 0.6407 0.1823
β4: FIM Estimate 0.0008364 0.03768 0.01982 0.1577 0.1575 -0.009847 0.08176 -0.009425 -0.3358 -0.3762
95% CI -0.09 - 0.09 -0.08 - 0.16 -0.03- 0.07 -0.84 - 1.15 -0.18 - 0.49 -0.11 - 0.09 -0.12 - 0.29 -0.07 - 0.05 -1.5 - 0.83 -0.65 - -0.09
p-Value 0.985 0.5199 0.4821 0.7463 0.3347 0.845 0.4209 0.777 0.5567 0.0101
β5: BBS Estimate -0.07378 -0.1856 -0.001744 0.4655 0.7937 0.1786 0.361 0.103 -0.7422 0.3472
95% CI -0.29 - 0.14 -0.48 - 0.1 -0.14 - 0.13 -1.97 - 2.9 -0.01 - 1.6 -0.06 - 0.42 -0.13 - 0.85 -0.05 - 0.27 -3.52 - 2.03 -0.31 - 1
p-Value 0.5 0.2018 0.9797 0.6969 0.0545 0.146 0.1425 0.2017 0.5855 0.2893
β6: SFR Estimate -3.899 12.23 50.6 54.62 43.15 0.2419 5.205 41.9 119.2 17.25
95% CI -16.44 - 8.64 -4.22 - 28.69 42.69 - 58.52 -82.83 - 192.1 -2.47 - 88.77 -14.65 - 15.14 -24.63 - 35.04 32.06 - 51.74 -49.16 - 287.6 -22.92 - 57.43
p-Value 0.5264 0.1377 < 0.0001 0.4195 0.0626 0.9735 0.7215 < 0.0001 0.1565 0.3836

ACE III, Addenbrooke’s Cognitive Examination III; BBS, the Berg Balance Scale; BI, Barthel Index; CI, confidence interval; FIM, functional independence measure; H2O2, hydrogen peroxide; NWS, non-stimulated whole saliva; SFR, salivary flow rate; SWS, stimulated whole saliva; UA, uric acid; XO, xanthine oxidase.