. 2022 May 6;13:897413. doi: 10.3389/fimmu.2022.897413

Table 6.

ROC analysis of salivary ischemia biomarkers.

		Cut off	AUC	95% CI	Sensitivity %	95% CI	Specificity %	95% CI
HS vs. C
XO activity	NWS	> 44.78	0.747	0.59 - 0.91	80	54.81% - 92.95%	66.67	48.78% - 80.77%
XO activity	SWS	> 40.56	0.593	0.41 - 0.78	60	35.75% - 80.18%	66.67	48.78% - 80.77%
XO specific activity	NWS	> 45.94	0.858	0.74 - 0.97	73.33	48.05% - 89.1%	83.33	66.44% - 92.66%
XO specific activity	SWS	> 37.54	0.824	0.67 - 0.99	80	54.81% - 92.95%	86.67	70.32% - 94.69%
XO output	NWS	< 14.18	0.502	0.28 - 0.73	53.33	30.12% - 75.19%	50	33.15% - 66.85%
XO output	SWS	< 30.95	0.693	0.53 - 0.86	66.67	41.71% - 84.82%	63.33	45.51% - 78.13%
H₂O₂ concentration	NWS	> 251.6	0.704	0.56 - 0.86	66.67	41.71% - 84.82%	56.67	39.2% - 72.62%
H₂O₂ concentration	SWS	> 325.4	0.733	0.59 - 0.88	73.33	48.05% - 89.1%	70	52.12% - 83.34%
UA concentration	NWS	> 65.44	0.735	0.59 - 0.89	66.67	41.71% - 84.82%	66.67	48.78% - 80.77%
UA concentration	SWS	< 57.01	0.609	0.42 - 0.8	66.67	41.71% - 84.82%	73.33	55.55% - 85.82%
IS vs. C
XO activity	NWS	> 49.61	0.92	0.82 - 1	86.67	62.12% - 97.63%	93.33	78.68% - 98.82%
XO activity	SWS	> 38.78	0.649	0.47 - 0.82	66.67	41.71% - 84.82%	56.67	39.2% - 72.62%
XO specific activity	NWS	> 50.3	0.973	0.94 - 1	93.33	70.18% - 99.66%	90	74.38% - 96.54%
XO specific activity	SWS	> 36.77	0.871	0.74 - 1	86.67	62.12% - 97.63%	83.33	66.44% - 92.66%
XO output	NWS	> 17.46	0.747	0.55 - 0.94	73.33	48.05% - 89.1%	83.33	66.44% - 92.66%
XO output	SWS	< 32.65	0.607	0.43 - 0.79	53.33	30.12% - 75.19%	56.67	39.2% - 72.62%
H₂O₂ concentration	NWS	> 357.6	0.998	0.99 - 1	100	79.61% - 100%	96.67	83.33% - 99.83%
H₂O₂ concentration	SWS	> 328.5	0.762	0.61 - 0.92	66.67	41.71% - 84.82%	73.33	55.55% - 85.82%
UA concentration	NWS	> 68.82	0.873	0.74 - 1	86.67	62.12% - 97.63%	80	62.69% - 90.49%
UA concentration	SWS	< 58.37	0.538	0.34 - 0.73	60	35.75% - 80.18%	66.67	48.78% - 80.77%
IS vs. HS
XO activity	NWS	> 49.08	0.836	0.68 - 0.99	86.67	62.12% - 97.63%	73.33	48.05% - 89.1%
XO activity	SWS	> 40.87	0.551	0.34 - 0.77	53.33	30.12% - 75.19%	46.67	24.81% - 69.88%
XO specific activity	NWS	> 59.75	0.764	0.6 - 0.93	66.67	41.71% - 84.82%	66.67	41.71% - 84.82%
XO specific activity	SWS	< 46.92	0.516	0.3 - 0.73	53.33	30.12% - 75.19%	53.33	30.12% - 75.19%
XO output	NWS	> 20.09	0.684	0.5 - 0.9	66.67	41.71% - 84.82%	66.67	41.71% - 84.82%
XO output	SWS	> 26.62	0.591	0.38 - 0.8	66.67	41.71% - 84.82%	53.33	30.12% - 75.19%
H₂O₂ concentration	NWS	> 392.6	0.96	0.9 - 1	93.33	70.18% - 99.66%	86.67	62.12% - 97.63%
H₂O₂ concentration	SWS	> 368.5	0.6	0.39 - 0.82	60	35.75% - 80.18%	66.67	41.71% - 84.82%
UA concentration	NWS	> 76.44	0.724	0.54 - 0.91	73.33	48.05% - 89.1%	66.67	41.71% - 84.82%
UA concentration	SWS	> 53.19	0.587	0.38 - 0.8	66.67	41.71% - 84.82%	53.33	30.12% - 75.19%

AUC, the area under the curve; C, Control group (n = 30); CI, confidence interval; H₂O₂, hydrogen peroxide; HS, hemorrhagic stroke group (n = 15); IS, ischemic stroke group (n = 15); NWS, non-stimulated whole saliva; SWS: stimulated whole saliva; UA, uric acid; XO, xanthine oxidase.